Activated PI3K-Delta Syndrome

Invitae Unlock™ Immunology provides clinicians with a comprehensive gene panel to evaluate patients with suspected primary immunodeficiency or immune-regulatory disorders. The test is billed to insurance first; when a claim is denied or the patient is uninsured, the program's sponsor covers the cost of testing. It supports diagnostic clarification, aids in variant-guided care decisions, and can inform family cascade testing when appropriate.

Invitae Unlock Immunology offers sponsored access to the Inborn Errors of Immunity and Cytopenias Panel, Invitae’s most comprehensive assay for evaluating inherited immune disorders and cytopenias. The panel includes genes tied to combined immunodeficiencies, immune dysregulation, and bone marrow failure, supporting clearer diagnosis and management. U.S. providers may order for eligible patients.

The navigateAPDS Program provides clinicians in the US, Canada, and Puerto Rico with free, comprehensive genetic testing for patients clinically suspected of APDS. By analyzing relevant immune genes (PIK3CD, PIK3R1) via Invitae’s PID / Inborn-Immunity panels, the program helps clarify diagnosis, guide immunological management, and support long-term care planning. Free post-test genetic counseling is included for all tested patients.