TTR Single-Gene Analysis
Detects pathogenic variants in the TTR gene associated with hereditary transthyretin amyloidosis (hATTR), supporting diagnosis and evaluation of hereditary risk.
Accessed through the NavigATTR Sponsored Testing Program•Sponsored by AstraZeneca, Ionis Pharmaceuticals•Performed by Prevention Genetics
Designed to help patients understand the purpose of testing and what to expect.
For patients
What this test and program do
This program offers no-cost genetic testing for adults in the U.S. who may be at risk for hereditary transthyretin amyloidosis (hATTR). Eligible patients can receive testing that includes analysis of the TTR gene, helping clarify whether symptoms, family history, or prior findings may be related to hATTR.
Who this may help
Could this be right for you or your family?
- Must be a U.S. resident and 18 years of age or older.
- Eligible if there is a family history of hereditary transthyretin amyloidosis (hATTR), a positive PYP scan, or a biopsy indicating amyloidosis.
- Patients with two or more red-flag symptoms suggestive of hATTR may also qualify.
- Testing must be ordered through a licensed health care professional.
What to expect
How the process works
- 1
Confirm Eligibility
Talk with your health care provider to determine whether you meet the program’s eligibility criteria and whether this test is appropriate for you.
- 2
Test Ordering
Your provider will order the test using the online portal or the program’s test requisition form.
- 3
Provide a Specimen
Your provider will collect the specimen and label it with at least two identifiers. Specimens are accepted Monday–Saturday, with holiday schedules posted in advance.
- 4
Receive Your Results
PreventionGenetics processes the test and sends results to your provider in about two weeks. Your provider will review the findings, and no-cost genetic counseling is available.
Cost & coverage
Understanding potential costs
If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.
Quality & privacy
How your sample and information are handled
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Common questions about this program
What is this program?
This is a no-cost genetic testing program for adults who may be at risk for hereditary transthyretin amyloidosis (hATTR). Eligible patients can receive testing that includes analysis of the TTR gene.
Who is eligible for testing?
You may qualify if you are 18 or older, live in the United States, and have a family history of hATTR, a positive PYP scan, biopsy findings for amyloidosis, or two or more red-flag symptoms. A health care provider must order the test.
What does the TTR test look for?
The test looks for genetic changes in the TTR gene that are known to cause hereditary transthyretin amyloidosis (hATTR). Results can help clarify diagnosis and hereditary risk.
Is this program really free?
Yes. The program covers the cost of the genetic test. There may be no-cost genetic counseling available to help answer questions before or after testing.
How do I get started?
Talk with your health care provider. They will confirm eligibility, order the test on your behalf, and explain how the specimen will be collected.
How long do results take?
Most results are returned to your provider about two weeks after the lab receives your sample and required paperwork.
Will someone help me understand my results?
Your provider will review your results with you. No-cost pre-test and post-test counseling is also available through an independent genetic counseling provider.
Questions to ask your doctor about TTR Single-Gene Analysis
- Do you think this test is appropriate for me based on my symptoms and history?
- How could the results of this test change my diagnosis or treatment plan?
- What are the potential limitations of this test that I should understand?
- Should any of my family members also be tested based on my results?
- How will we follow up after the results are available?
Notes
See an issue with this program?