NeuroNavigATTR (66 genes)
Detects pathogenic TTR variants linked to hereditary transthyretin amyloidosis (hATTR), supporting evaluation of patients with peripheral neuropathy or autonomic symptoms
Accessed through the NavigATTR Sponsored Testing Program•Sponsored by AstraZeneca, Ionis Pharmaceuticals•Performed by Prevention Genetics
Designed to help patients understand the purpose of testing and what to expect.
For patients
What this test and program do
If you or your doctor suspect that your nerve problems, such as numbness, tingling, pain, or issues with blood pressure, digestion, or other automatic body functions, could be related to a genetic condition called hereditary transthyretin amyloidosis (hATTR), the NavigATTR program can help. Through the NeuroNavigATTR test, eligible adults in the U.S. can get genetic testing at no cost to look for changes in the TTR gene and other related genes that may explain your symptoms. Identifying an hATTR diagnosis matters because it can open the door to treatments and help your family understand their own risk. The program is sponsored by AstraZeneca and Ionis Pharmaceuticals, and testing is performed by Prevention Genetics.
Who this may help
Could this be right for you or your family?
- To qualify, all of the following must be met:
- The patient is 18 or older
- The patient lives in the United States
- The patient meets at least one of the following:
- At least one of the following:
- A family history of hereditary ATTR (hATTR) amyloidosis
- A positive cardiac nuclear scan (99mTc-PYP/DPD/HMDP uptake on bone scintigraphy) with no abnormal (monoclonal) protein in the blood or urine
- A biopsy positive for amyloidosis
- At least one symptom from two separate categories below:
- Autonomic dysfunction
- Bladder dysfunction
- Early satiety
- Erectile dysfunction
- Orthostatic hypotension
- Bilateral carpal tunnel syndrome
- Gastrointestinal
- Nausea and vomiting
- Alternating bouts of diarrhea/constipation
- Heart disease
- Arrhythmias
- Heart failure or cardiomyopathy
- Edema
- Fatigue
- Shortness of breath
- Lumbar spinal stenosis
- Motor dysfunction
- Difficulty walking
- Impaired balance
- Muscle weakness
- Neurological disease
- Numbness and tingling in feet and/or hands
- Pain in extremities
- Sensitivity to pain and temperature
- Renal issues
- Proteinuria
- Renal insufficiency/failure
- Testing is ordered by a qualified healthcare provider
What to expect
How the process works
- 1
Confirm Eligibility
Talk with your health care provider to determine whether you meet the program’s eligibility criteria and whether this test is appropriate for you.
- 2
Test Ordering
Your provider will order the test using the online portal or the program’s test requisition form.
- 3
Provide a Specimen
Your provider will collect the specimen and label it with at least two identifiers. Specimens are accepted Monday–Saturday, with holiday schedules posted in advance.
- 4
Receive Your Results
PreventionGenetics processes the test and sends results to your provider in about two weeks. Your provider will review the findings, and no-cost genetic counseling is available.
Cost & coverage
Understanding potential costs
If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.
Quality & privacy
How your sample and information are handled
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Common questions about this program
What is the NavigATTR genetic testing program for hereditary ATTR amyloidosis?
The NavigATTR program offers no-cost genetic testing through a test called NeuroNavigATTR, which looks at 66 genes including the TTR gene to help determine whether your symptoms may be caused by hereditary transthyretin amyloidosis (hATTR). Neuropathic hATTR can affect the nerves that control movement, sensation, and automatic body functions like heart rate and digestion, and it can look a lot like other types of neuropathy. Getting a clear genetic answer can help you and your doctor figure out the right path forward, including whether specific treatments may be available for you.
Is NavigATTR genetic testing for hereditary ATTR amyloidosis really free?
Yes, the NeuroNavigATTR test is provided at absolutely no cost to you. AstraZeneca and Ionis Pharmaceuticals sponsor the NavigATTR program and cover the full cost of testing. You will not receive a bill, and there are no copays or deductibles to worry about. Your doctor simply needs to order the test for you.
What kind of sample is needed for the NavigATTR hereditary ATTR amyloidosis test?
The NeuroNavigATTR test can be done using a blood draw, a saliva sample, or a buccal swab, which is a simple cheek swab. Your doctor's office will receive a sample collection kit to make the process easy. The sample is then sent to Prevention Genetics, the lab that performs the testing.
How long does it take to get results from the NavigATTR hereditary ATTR amyloidosis test?
Results from the NeuroNavigATTR test are typically available in about 2 to 3 weeks after your sample reaches the lab. Your ordering doctor will receive the results and go over them with you. If you have questions while you wait, your doctor's office can help you stay informed about the process.
Does the NavigATTR program for hereditary ATTR amyloidosis include genetic counseling?
Yes, the NavigATTR program includes genetic counseling support as part of the no-cost program. Genetic counselors can help you understand what your test results mean, what they could mean for your family members, and what steps to consider next. This support is available to help you feel confident and informed throughout the process.
How do I get the NavigATTR no-cost genetic test for hereditary ATTR amyloidosis?
The NeuroNavigATTR test must be ordered by a qualified health care provider. If you are experiencing symptoms like unexplained neuropathy or autonomic dysfunction, talk to your doctor about whether this no-cost genetic test could be right for you. Your doctor can order a sample collection kit and guide you through the process from start to finish.
Who qualifies for NavigATTR Hereditary ATTR Amyloidosis genetic testing?
Patients may qualify for NavigATTR if they meet the program's eligibility criteria:
- Must be a U.S. resident and 18 years of age or older.
- May qualify with a family history of hereditary transthyretin amyloidosis (hATTR), a positive PYP scan, or a biopsy consistent with amyloidosis.
- Patients with two or more red-flag symptoms suggestive of hATTR may also be eligible.
- Testing must be ordered by a licensed health care professional.
Questions to ask your doctor about NeuroNavigATTR (66 genes)
- Do you think this test is appropriate for me based on my symptoms and history?
- How could the results of this test change my diagnosis or treatment plan?
- What are the potential limitations of this test that I should understand?
- Should any of my family members also be tested based on my results?
- How will we follow up after the results are available?
Notes
See an issue with this program?