FCSNext
5-gene NGS panel detecting pathogenic variants causing familial chylomicronemia syndrome (FCS) and other monogenic hypertriglyceridemia.
Accessed through the FCS Seek Sponsored Testing Program•Sponsored by Arrowhead Pharmaceuticals•Performed by Ambry Genetics
Designed to help patients understand the purpose of testing and what to expect.
For patients
What this test and program do
Familial Chylomicronemia Syndrome, or FCS, is a rare genetic condition that causes extremely high triglyceride levels and can lead to repeated bouts of pancreatitis and other serious complications. If your doctor suspects FCS might be behind your symptoms, the FCS Seek program offers a genetic test called FCSNext that looks at five genes known to cause severe triglyceride problems. The test is fully sponsored by Arrowhead Pharmaceuticals, so there is no cost to you. Results can give you and your doctor a clearer diagnosis, help guide your treatment plan, and let you know whether close family members should also be tested.
Who this may help
Could this be right for you or your family?
- To qualify, all of the following must be met:
- The patient is 17 years of age or older
- A fasting triglyceride (blood-fat) level above 600 mg/dL in the past 12 months
- The patient has not had genetic testing for FCS before
What to expect
How the process works
- 1
Get the kit
Your clinician orders an Ambry test kit for you.
- 2
Collect sample
Follow the kit instructions to provide the sample and package it as directed.
- 3
Return & review
Send the kit back; your clinician will review the results with you.
Cost & coverage
Understanding potential costs
If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.
Quality & privacy
How your sample and information are handled
Testing is performed by Ambry Genetics, a CLIA-certified laboratory (CLIA 05D0981414). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Common questions about this program
What is the FCS Seek genetic testing program for Familial Chylomicronemia Syndrome?
FCS Seek is a sponsored genetic testing program that helps people find out whether their dangerously high triglycerides are caused by Familial Chylomicronemia Syndrome or a related inherited condition. The program uses a test called FCSNext, which is a 5-gene panel performed by Ambry Genetics. It is designed for people whose doctors suspect a genetic cause behind their severe triglyceride levels, recurrent pancreatitis, or related symptoms.
Is the FCS Seek genetic test for FCS really free, and who pays for it?
Yes, the FCSNext test through the FCS Seek program is completely free to you. Arrowhead Pharmaceuticals sponsors the program and covers the full cost of testing. You will not receive a bill, and there is no copay or deductible to worry about.
What kind of sample is needed for the FCS Seek genetic test?
The FCSNext test can be performed using a whole blood sample, a buccal swab (a simple cheek swab), or a saliva sample. In many cases, a buccal swab collection kit is sent directly to your home so you can collect the sample yourself and mail it to the lab. Your doctor will help determine which sample type is best for you.
How long does it take to get results from the FCS Seek FCSNext test?
Results from the FCSNext test are typically available about 2 to 3 weeks after Ambry Genetics receives your sample. Your ordering doctor will be notified when results are ready and will go over the findings with you, including what they mean for your diagnosis, treatment, and family.
Can FCS Seek genetic testing results help my family members understand their risk for Familial Chylomicronemia Syndrome?
Yes, one of the important benefits of the FCSNext test is that it can support cascade testing for your close relatives. If your results identify a genetic change linked to FCS or a related condition, your family members may also benefit from genetic testing to find out if they carry the same variant. Your healthcare provider or a genetic counselor can help you understand what the results mean for your family.
Do I need a doctor to order the FCS Seek test for Familial Chylomicronemia Syndrome?
Yes, the FCSNext test through the FCS Seek program must be ordered by a healthcare provider. If you think you might benefit from genetic testing for FCS, talk to your doctor about whether this program is right for you. Your doctor can place the order and guide you through the process.
Who qualifies for FCS Seek Familial Chylomicronemia Syndrome genetic testing?
Patients may qualify for FCS Seek if they meet the program's eligibility criteria:
- You are 17+ years old
- You’ve had a fasting triglyceride >600 mg/dL (≥6.77 mmol/L) within the past 12 months.
- Not eligible if: you’re <17 or you’ve had prior genetic testing for FCS.
Questions to ask your doctor about FCSNext
- Do you think this test is appropriate for me based on my symptoms and history?
- How could the results of this test change my diagnosis or treatment plan?
- What are the potential limitations of this test that I should understand?
- Should any of my family members also be tested based on my results?
- How will we follow up after the results are available?
Notes
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