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Nephrology / GeneticsChronic Kidney Disease (CKD)APOL1-Mediated Kidney Disease (AMKD)

Renasight™ Genetic Kidney Panel

Genetic test analyzing 300+ genes linked to kidney disease, helping identify inherited causes of CKD, nephrolithiasis, and related renal conditions.

Accessed through the Renasight™ Sponsored Testing Program•Sponsored by Vertex Pharmaceuticals•Performed by Natera

Designed to help patients understand the purpose of testing and what to expect.

For patients

What this test and program do

Certain variants in a gene called APOL1 are more common in people of African ancestry and can play a hidden role in chronic kidney disease (CKD). The Renasight sponsored testing program, funded by Vertex Pharmaceuticals, gives eligible patients a chance to find out whether these genetic variants may be contributing to their kidney disease, at absolutely no cost to you. Understanding the genetic piece of the puzzle can help you and your doctor make more informed decisions about how to manage your kidney health going forward.

Who this may help

Could this be right for you or your family?

  • Patients qualify for no-charge sponsored testing if they meet all of the following:
    • Self-identify as African American, African, or Afro-Caribbean
    • Diagnosed with non-diabetic chronic kidney disease (CKD)
    • Have no prior history of dialysis or kidney transplant

What to expect

How the process works

  1. 1

    Confirm Eligibility

    Your provider will review program criteria with you to confirm that you qualify and obtain your consent for genetic testing.

  2. 2

    Provide a Sample

    Give a blood or buccal (cheek swab) sample using a Renasight™ collection kit provided by your care team.

  3. 3

    Receive Results

    Results are typically ready in about 3 weeks. Discuss them with your provider to understand what they may mean for your kidney health.

Cost & coverage

Understanding potential costs

If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.

Quality & privacy

How your sample and information are handled

Testing is performed by Natera, a CLIA-certified laboratory (CLIA 05D1082992) and College of American Pathologists (CAP) certified laboratory (CAP 8737934). Your sample is processed using validated methods and quality controls to support reliable genetic results.

Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.

FAQ

Common questions about this program

What is the Renasight sponsored genetic testing program for chronic kidney disease?

The Renasight sponsored testing program is a no-cost genetic testing program designed for eligible patients of African ancestry who have been diagnosed with chronic kidney disease. It looks for variants in the APOL1 gene that are linked to a condition called APOL1-mediated kidney disease, or AMKD. The test is performed by Natera, and the program is funded by Vertex Pharmaceuticals so there is no charge to you.

Is the Renasight APOL1 genetic test for kidney disease really free?

Yes, the Renasight sponsored testing program is provided at no cost to eligible patients. Vertex Pharmaceuticals covers the full cost of testing, so you will not receive a bill, a copay, or any other charge. You simply need a physician order to get started.

Why does APOL1 genetic testing matter if I have chronic kidney disease?

APOL1 gene variants are found more often in people of African ancestry and can contribute to kidney disease in ways that might not be obvious from standard tests alone. Knowing whether you carry these variants can help your doctor better understand why your kidneys are declining and may open the door to more tailored management of your condition. A diagnosis of APOL1-mediated kidney disease can only be made by your healthcare provider after reviewing all of your health information, including genetic test results.

How do I get Renasight sponsored genetic testing for chronic kidney disease?

The Renasight sponsored testing program requires a physician order, so the first step is to talk with your healthcare provider about whether this program is right for you. Your doctor can determine if you meet the program's eligibility criteria and place the order on your behalf. There is no cost to you for the testing.

Is genetic counseling available with the Renasight CKD testing program?

Natera offers genetic information sessions that can help you understand your results and what they may mean for your health. If you have questions before or after testing, you can ask your healthcare provider about scheduling a session. These resources are designed to help you feel supported and informed throughout the process.

Who qualifies for Renasight Chronic Kidney Disease genetic testing?

Patients may qualify for Renasight if they meet the program's eligibility criteria:

  • Patients qualify for no-charge sponsored testing if they meet all of the following:
    • Self-identify as African American, African, or Afro-Caribbean
    • Diagnosed with non-diabetic chronic kidney disease (CKD)
    • Have no prior history of dialysis or kidney transplant

Test details

  • ConditionsChronic Kidney Disease (CKD), APOL1-Mediated Kidney Disease (AMKD)
  • Test typeLarge NGS Panel
  • Genes / markers
    407
  • Key genes / markersAPOL1
  • SpecimenWhole blood•Saliva
  • Turnaround time3 Weeks
  • LabNatera
  • Program regionUnited States

Next steps

Share this information with your nephrologist or genetic specialist. They can help determine whether this test and program are appropriate for you.

Or ask your doctor to search for this test by name at Natera.

Questions to ask your doctor about Renasight™ Genetic Kidney Panel

  1. Do you think this test is appropriate for me based on my symptoms and history?
  2. How could the results of this test change my diagnosis or treatment plan?
  3. What are the potential limitations of this test that I should understand?
  4. Should any of my family members also be tested based on my results?
  5. How will we follow up after the results are available?

Notes

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