Uncovering Rare Obesity Gene Pane
An 87-gene panel assessing monogenic and syndromic causes of early-onset obesity, including genes involved in leptin–melanocortin signaling and ciliopathies.
Accessed through the Uncovering Rare Obesity™ Sponsored Testing Program•Sponsored by Rhythm Pharmaceuticals•Performed by Prevention Genetics
Designed to help patients understand the purpose of testing and what to expect.
For patients
What this test and program do
This program offers no-cost genetic testing to help determine whether early-onset or severe obesity may have an underlying genetic cause. Eligible patients in the U.S., its territories, and Canada can be tested for variants across 87 genes linked to rare forms of obesity, including Bardet–Biedl syndrome. Testing is ordered by a healthcare provider, with sample collection kits and lab processing covered by the sponsor.
Who this may help
Could this be right for you or your family?
- You have early-onset, severe obesity or a suspected genetic syndrome where obesity is a major feature
- You are 18 or younger with a BMI at or above the 97th percentile, OR
- You are 19 or older with a BMI of 40 or higher and a history of childhood obesity
- You are an immediate family member of certain previously tested patients
- You have symptoms suggesting Bardet–Biedl syndrome (BBS)
- You live in the U.S., its territories, or Canada
What to expect
How the process works
- 1
Your provider gets a test kit
Your provider will order the kit they need for your sample. Many clinics keep kits on hand so testing can begin right away.
- 2
Your sample is collected
Your provider completes the test form with your information and collects your sample during your visit.
- 3
Your sample is sent to the lab
Your provider submits your test online, prints the forms, signs where needed, and sends everything to the lab using the prepaid materials in the kit.
- 4
Your provider receives results
After your sample is sent, your provider can track your test and will receive your results when they are ready. They will contact you to review them together.
Cost & coverage
Understanding potential costs
If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.
Quality & privacy
How your sample and information are handled
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Common questions about this program
What does this test look for?
This test analyzes 87 genes linked to rare genetic forms of obesity, including conditions that affect appetite regulation or cause syndromic obesity.
Who is eligible for this program?
Testing is available for people with early-onset or severe obesity, those with suspected genetic syndromes such as Bardet–Biedl syndrome (BBS), or eligible family members. You must live in the U.S., its territories, or Canada.
Is the test really no cost?
Yes. If you meet the program criteria, the genetic test and sample collection kit are provided at no cost through this sponsored program.
What type of sample is required?
Your provider may collect either a blood sample or a buccal swab, depending on the kit you receive.
How long does it take to get results?
Results are usually available about three weeks after the lab receives your sample and completed paperwork.
Is genetic counseling included?
Yes. The program includes one pre-test and one post-test session through Metis Genetics. Patients or caregivers can schedule at 1-844-463-8474 or by email.
Questions to ask your doctor about Uncovering Rare Obesity Gene Pane
- Do you think this test is appropriate for me based on my symptoms and history?
- How could the results of this test change my diagnosis or treatment plan?
- What are the potential limitations of this test that I should understand?
- Should any of my family members also be tested based on my results?
- How will we follow up after the results are available?
Notes
See an issue with this program?