Uncovering Periodic Paralysis Panel
Genetic testing for 6 genes associated with primary periodic paralysis, including HyperPP, HypoPP, PMC, and ATS, to help clarify the cause of episodic muscle weakness.
Accessed through the Uncovering Periodic Paralysis Sponsored Testing Program•Sponsored by Xeris Pharmaceuticals•Performed by Prevention Genetics
Designed to support clinical decision-making and ordering in your practice.
For healthcare providers
Overview
The Uncovering Periodic Paralysis Program offers no-cost genetic testing and genetic counseling for individuals with episodic muscle weakness or temporary paralysis often triggered by common factors associated with primary hyperkalemic or hypokalemic periodic paralysis. This testing program is sponsored by Xeris Pharmaceuticals.
When to consider this test
Patient selection
- Adult U.S.-based patients (≥18 years) with recurrent episodes of muscle weakness/paralysis or post-attack pain
- Clinical history suggesting primary periodic paralysis with attacks triggered by known HyperPP or HypoPP precipitating factors
- Indications consistent with:
- HyperPP: episodic weakness with serum potassium >4.5 mEq/L
- HypoPP: episodic weakness with hypokalemia (<2.5 mEq/L)
Workflow
How to use this program
- 1
Assess Eligibility
Confirm the patient meets criteria and discuss indications for testing.
- 2
Order the Test
Order via the online portal or paper TRF. Choose whole blood, saliva, or buccal swab based on clinical need.
- 3
Collect and Ship Sample
Collect and label specimens with two identifiers. Ship Monday–Saturday per standard instructions.
- 4
Review Test Results
Results return in ~3 weeks. Discuss findings with the patient and document follow-up as appropriate.
Billing overview
Program billing
For eligible patients, the sponsor has arrangements with the laboratory that may reduce or cover some or all of the patient's out-of-pocket cost. Actual cost and patient responsibility vary by program criteria. Refer to lab or sponsor materials for details.
Quality & privacy
Laboratory quality & data handling
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Frequently asked questions
Which disorders does this test evaluate?
This 6-gene panel evaluates the primary skeletal muscle channelopathies: Hyperkalemic Periodic Paralysis, Hypokalemic Periodic Paralysis, Paramyotonia Congenita, and Andersen–Tawil Syndrome.
Who is eligible for testing?
Adults (≥18 years) in the U.S. or U.S. territories with recurrent muscle weakness/paralysis or post-attack pain and episodes triggered by known HyperPP or HypoPP factors. Eligibility includes supporting biochemical features where available (e.g., potassium >4.5 mEq/L for HyperPP or <2.5 mEq/L for HypoPP).
What specimens are accepted?
Whole blood, saliva, or buccal swab samples are accepted. All specimens must be labeled with two identifiers.
How long is the turnaround time?
Results are typically available about 3 weeks after PreventionGenetics receives the specimen and required documentation.
Are genetic counseling services included?
No-cost genetic counseling with a third-party service (provided by Genome Medical), is available to patients through this sponsored testing program. Pre-test and post-test genetic counseling appointments are available to all individuals eligible for the Uncovering Periodic Paralysis genetic testing program. Learn more.
Are there geographic restrictions?
Yes. Testing is available only for patients who reside in the U.S. or U.S. territories.
Can family members be tested?
Family members may qualify if they meet clinical eligibility criteria and reside in the appropriate geography.
See an issue with this program?