NeuroNavigATTR (66 genes)
Detects pathogenic TTR variants linked to hereditary transthyretin amyloidosis (hATTR), supporting evaluation of patients with peripheral neuropathy or autonomic symptoms
Accessed through the NavigATTR Sponsored Testing Program•Sponsored by AstraZeneca, Ionis Pharmaceuticals•Performed by Prevention Genetics
Designed to support clinical decision-making and ordering in your practice.
For healthcare providers
Overview
The NeuroNavigATTR program offers no-cost TTR gene testing for adult U.S. patients with neuropathy or autonomic dysfunction where hATTR is part of the differential diagnosis. Neuropathic ATTR involves peripheral and autonomic nerve involvement and may mimic other hereditary or acquired neuropathies. Genetic testing helps distinguish hATTR polyneuropathy from other neuropathies and from wild-type ATTR cardiomyopathy. Testing for eligible patients
When to consider this test
Patient selection
- Age and residency: Patient is an adult (≥18 years) and resides in the United States.
- Clinical criteria: Patient has a family history of hATTR, positive PYP, biopsy evidence of amyloidosis, or ≥2 red-flag symptoms concerning for hATTR.
- Ordering requirements: Testing must be ordered by a qualified health care provider in accordance with program requisition requirements.
Workflow
How to use this program
- 1
Assess Patient Eligibility
Confirm that the patient meets program criteria and review the purpose and scope of testing before proceeding with the requisition or portal order.
- 2
Order the Test
Place the order through the online portal or requisition form and ensure all required patient and clinical information is included for processing.
- 3
Collect and Label Specimen
Collect the specimen using the appropriate tube and label with two identifiers. Specimens are accepted Monday–Saturday, with posted holiday exceptions.
- 4
Review and Discuss Results
Results are typically available in about two weeks. Discuss findings with the patient and caregiver as appropriate. Genetic counseling support is available for both providers and patients.
Billing overview
Program billing
For eligible patients, the sponsor has arrangements with the laboratory that may reduce or cover some or all of the patient's out-of-pocket cost. Actual cost and patient responsibility vary by program criteria. Refer to lab or sponsor materials for details.
Quality & privacy
Laboratory quality & data handling
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Frequently asked questions
Which patients may qualify for this program?
Eligible patients are ≥18 years old, U.S. residents, and meet criteria such as family history of hATTR, positive PYP, biopsy consistent with amyloidosis, or ≥2 red-flag symptoms related to neuropathy or autonomic dysfunction.
What does the NeuroNavigATTR test include?
The program provides no-cost TTR gene testing to support evaluation of suspected hereditary transthyretin amyloidosis (hATTR) in patients with peripheral neuropathy, autonomic symptoms, or a relevant family history.
How do I order testing?
Testing can be ordered through the online portal or via the test requisition form. Ensure all clinical and patient information is complete for timely processing.
What are the specimen requirements?
Collect the specimen using the appropriate collection tube. Label all containers with at least two identifiers (name, DOB, or ID). Specimens are accepted Monday–Saturday; holiday schedules are posted in advance.
When should I expect results?
Most results are available about two weeks after PreventionGenetics receives the specimen and all required documentation.
Is genetic counseling available for patients?
Yes. Genome Medical offers no-cost pre-test or post-test genetic counseling via telephone for patients referred through this program. You may refer a patient for one pre-test or one post-test session by checking the appropriate boxes in the counseling section of the requisition form.
Can providers consult with Genome Medical?
Genome Medical counseling is patient-facing only. For provider questions, refer to the program materials or PreventionGenetics support contacts.
See an issue with this program?