CardioNavigATTR (36 genes)
Covers the TTR gene plus 35 other cardiomyopathy genes to identify variant-associated risk for hereditary transthyretin amyloidosis (hATTR) and related cardiac conditions
Accessed through the NavigATTR Sponsored Testing Program•Sponsored by AstraZeneca, Ionis Pharmaceuticals•Performed by Prevention Genetics
Designed to support clinical decision-making and ordering in your practice.
For healthcare providers
Overview
The CardioNavigATTR program is a no-charge genetic testing initiative for adult U.S. patients meeting specific criteria who are at risk for hATTR or cardiomyopathy. It offers a 36-gene cardiomyopathy panel (including TTR) to support diagnostic investigation, guide clinical decision-making, and identify hereditary risk in the cardiology setting.
When to consider this test
Patient selection
- Age and residency: Adult (≥18 years) patient residing in the United States.
- Clinical criteria: Family history of hATTR, positive PYP, biopsy evidence of amyloidosis, or ≥2 red-flag symptoms raising concern for hATTR.
- Ordering requirements: Testing must be ordered by a qualified health care professional in accordance with the program’s requisition form.
Workflow
How to use this program
- 1
Assess Patient Eligibility
Confirm that the patient meets program criteria and review the purpose and scope of testing before proceeding with the requisition or portal order.
- 2
Order the Test
Place the order through the online portal or requisition form and ensure all required patient and clinical information is included for processing.
- 3
Collect and Label Specimen
Collect the specimen using the appropriate tube and label with two identifiers. Specimens are accepted Monday–Saturday, with posted holiday exceptions.
- 4
Review and Discuss Results
Results are typically available in about two weeks. Discuss findings with the patient and caregiver as appropriate. Genetic counseling support is available for both providers and patients.
Billing overview
Program billing
For eligible patients, the sponsor has arrangements with the laboratory that may reduce or cover some or all of the patient's out-of-pocket cost. Actual cost and patient responsibility vary by program criteria. Refer to lab or sponsor materials for details.
Quality & privacy
Laboratory quality & data handling
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Frequently asked questions
Which patients may qualify for this program?
Eligible patients are ≥18, U.S. residents, and meet criteria such as a family history of hATTR, positive PYP, biopsy indicating amyloidosis, or ≥2 red-flag symptoms.
What does the CardioNavigATTR test include?
This sponsored program provides a 36-gene hereditary cardiomyopathy panel, including TTR. It supports evaluation of suspected hATTR and inherited cardiac disease.
How do I order testing?
Testing can be ordered through the program’s online portal or the paper requisition form. Ensure all clinical and patient information is complete before submission.
What specimens are accepted?
Collect the sample using the appropriate collection tube and label with at least two identifiers (name, DOB, or ID). Specimens are accepted Monday–Saturday.
How long is the turnaround time?
Results are typically ready in about two weeks after PreventionGenetics receives the specimen and required documentation.
Is genetic counseling available for my patients?
Yes. Genome Medical provides no-cost pre-test or post-test genetic counseling for patients through this program. Counseling is delivered by telephone and supports education, informed consent, and result interpretation. You may refer a patient for one pre-test or one post-test session by checking the appropriate boxes on the requisition form.
Are geneticists or counselors available to support providers?
Genome Medical counseling is patient-facing only. For ordering or technical questions, refer to the program materials or PreventionGenetics support resources.
See an issue with this program?