Familial Chylomicronemia Panel
7-gene genetic test at no cost for individuals with suspected FCS and severe hypertriglyceridemia, helping confirm diagnosis and guide care.
Accessed through the Familial Chylomicronemia Syndrome (FCS) Sponsored Testing Program•Sponsored by Ionis Pharmaceuticals•Performed by Prevention Genetics
Designed to support clinical decision-making and ordering in your practice.
For healthcare providers
Overview
This program offers complimentary genetic testing for patients in the U.S. or Canada with severe refractory hypertriglyceridemia, defined as two or more fasting triglyceride levels >880 mg/dL (10 mmol/L) without secondary causes. Testing evaluates genetic contributors to FCS and related disorders, enabling more accurate diagnosis of persistent sHTG. Pre- and post-test genetic counseling through Genome Medical is included at no cost.
When to consider this test
Patient selection
- Patient must reside in the United States or Canada.
- Evidence of severe refractory hypertriglyceridemia (sHTG), defined as ≥2 consecutive fasting triglyceride levels > 880 mg/dL (10 mmol/L).
- No secondary causes or medical conditions known to explain sHTG.
- Patient has provided informed consent.
Workflow
How to use this program
- 1
Confirm Eligibility & Discuss Testing
Evaluate whether the patient meets eligibility criteria and review the testing process. Pre-test counseling through Genome Medical is available.
- 2
Order the Test
Order using the appropriate U.S. or Canadian requisition form. Kits can be requested as needed.
- 3
Collect & Ship Specimen
Collect blood, saliva, or buccal samples. Label with two identifiers. Follow stability guidance (blood stable 48 hours at room temp; saliva/buccal at room temp). Ship Monday–Saturday.
- 4
Review Results & Offer Counseling
Results return in about 18 days. Discuss findings with the patient. Post-test counseling through Genome Medical is available.
Billing overview
Program billing
For eligible patients, the sponsor has arrangements with the laboratory that may reduce or cover some or all of the patient's out-of-pocket cost. Actual cost and patient responsibility vary by program criteria. Refer to lab or sponsor materials for details.
Quality & privacy
Laboratory quality & data handling
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Frequently asked questions
What does this program provide?
The program offers no-cost genetic testing for patients with severe refractory hypertriglyceridemia and optional third-party genetic counseling through Genome Medical. Kits and shipping materials can be requested as needed.
Which patients qualify?
Eligible patients reside in the U.S. or Canada and have ≥2 fasting triglyceride measurements >880 mg/dL (10 mmol/L) with no secondary causes of sHTG. Informed consent is required.
What genes are included?
The panel analyzes seven genes associated with familial chylomicronemia syndrome and severe hypertriglyceridemia: APOA5, APOC2, CREB3L3, GPD1, GPIHBP1, LMF1, and LPL. These genes help identify monogenic causes of persistent sHTG.
How do I order the test?
Order using the U.S. or Canadian requisition form. Blood, saliva, and buccal specimens are accepted. Kits can be requested through the kit order form.
What are the specimen requirements?
Blood specimens must not be frozen and should be kept insulated based on temperature conditions. Saliva and buccal samples may be shipped at room temperature. All samples require two patient identifiers.
How long is the turnaround time?
Results are typically returned in approximately 18 days after PreventionGenetics receives the specimen and required paperwork.
Is genetic counseling included?
Yes. Both pre-test and post-test genetic counseling are available at no cost through Genome Medical.
See an issue with this program?