Invitae Arrhythmia and Cardiomyopathy Comprehensive Panel
Comprehensive genetic test evaluating key genes linked to inherited arrhythmias and cardiomyopathies. Helps clarify diagnosis, guide management, and assess familial risk.
Accessed through the Mission: Genome Sponsored Testing Program•Sponsored by Rocket Pharma•Performed by Invitae | Labcorp
Designed to support clinical decision-making and ordering in your practice.
For healthcare providers
Overview
The Mission: Genome – Danon Disease Program offers no-charge Invitae testing for US-based patients with clinical suspicion of Danon disease. Testing includes LAMP2 as part of the Invitae Arrhythmia and Cardiomyopathy Panel. Eligible patients also receive no-charge post-test genetic counseling to support result interpretation and follow-up care.
When to consider this test
Patient selection
- Patient must reside in the United States.
- Patient is 40 years of age or younger
- Provider has a high clinical suspicion for an inherited cardiomyopathy
- Patient meets at least one of the following:
- Documented family history of Danon disease
- Cardiomyopathy diagnosis not attributable to acquired etiologies (e.g., medications, viral myocarditis)
Workflow
How to use this program
- 1
Submit an order
Place the order online or via paper TRF. Include the patient’s insurance information for benefits investigation.
- 2
Collect specimen
Collect a blood, buccal, or saliva specimen using a Labcorp kit and follow standard collection procedures.
- 3
Receive results
Turnaround time is typically 10–21 days from specimen receipt. Results will be available through your Labcorp portal.
Billing overview
Program billing
For eligible patients, the sponsor has arrangements with the laboratory that may reduce or cover some or all of the patient's out-of-pocket cost. Actual cost and patient responsibility vary by program criteria. Refer to lab or sponsor materials for details.
Quality & privacy
Laboratory quality & data handling
Testing is performed by Invitae | Labcorp, a CLIA-certified laboratory (CLIA 05D2040778). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Frequently asked questions
What does the Danon Disease Program provide?
Free, sponsored genetic testing for eligible U.S. patients under 40 when Danon disease is suspected. Testing uses Invitae’s cardiomyopathy or hypertrophic cardiomyopathy panel, which includes LAMP2. Post-test genetic counseling is also available at no cost.
Which patients qualify?
Patients must be in the U.S. and 40 or younger, and meet at least one of: a family history of Danon disease, or a cardiomyopathy diagnosis not due to acquired causes (e.g., exclude viral, drug-induced).
How do I order the test?
Obtain patient consent, then submit the order through Invitae’s clinician portal or requisition form. Collect a sample via Invitae kit and send to the lab for analysis.
Which panel is used?
Either Invitae’s Arrhythmia and Cardiomyopathy Comprehensive Panel or the Invitae Hypertrophic Cardiomyopathy Panel — both include LAMP2 and can detect variants relevant to Danon disease.
What is the expected turnaround time?
Results are typically reported within 10–21 days after receipt of the specimen.
Is genetic counseling available?
Yes. All patients tested under the program have access to no-charge post-test genetic counseling through Labcorp Genetics, to help interpret results and support follow-up care.
How should results be used in clinical care?
A positive result confirms Danon disease and may prompt cardiac monitoring, cardiology referral, family screening, and long-term care planning. If results are negative or uncertain, further evaluation may still be warranted based on clinical suspicion.
See an issue with this program?