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Hepatology / GeneticsCholestasisAlagille SyndromeFamilial Intrahepatic Cholestasis (PFIC)

Ipsen-Sponsored Cholestasis Panel (PEDS)

Comprehensive analysis of 110 genes associated with PFIC, ALGS, and other cholestatic liver diseases to support diagnosis, guide management, and inform family risk.

Accessed through the Cholestasis Genetic Testing Sponsored Testing Program•Sponsored by Ipsen•Performed by Invitae | Labcorp

Designed to support clinical decision-making and ordering in your practice.

For healthcare providers

Overview

This program offers no-charge comprehensive genetic testing for patients in the US or Canada with suspected inherited cholestatic liver disease. The Invitae Cholestasis Panel evaluates key genes associated with PFIC, ALGS, and other cholestatic disorders. Clinicians receive actionable results, and patients are eligible for complimentary post-test genetic counseling.

When to consider this test

Patient selection

  • Patient resides in the United States
  • No known extrahepatic disorder explaining cholestasis (e.g., biliary atresia)
  • And one of the following applies:
    • Current or past cholestasis with no identified cause
    • Unexplained chronic liver disease, including jaundice or persistent liver test abnormalities

Workflow

How to use this program

  1. 1

    Order Test

    Confirm eligibility, obtain consent, and place the order through the Invitae portal.

  2. 2

    Collect Sample

    Use an Invitae kit for specimen collection. Ship at no cost using the included return label.

  3. 3

    Review Results

    View results online and use available tools to support patient counseling and care decisions.

Billing overview

Program billing

For eligible patients, the sponsor has arrangements with the laboratory that may reduce or cover some or all of the patient's out-of-pocket cost. Actual cost and patient responsibility vary by program criteria. Refer to lab or sponsor materials for details.

Quality & privacy

Laboratory quality & data handling

Testing is performed by Invitae | Labcorp, a CLIA-certified laboratory (CLIA 05D2040778). Your sample is processed using validated methods and quality controls to support reliable genetic results.

Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.

FAQ

Frequently asked questions

Who qualifies for testing?

US-based patients who:

  1. Are not diagnosed with an extrahepatic disorder (e.g., biliary atresia), and
  2. Either:
  • Have current or historical cholestasis without a known cause, or
  • Have unexplained chronic liver disease with jaundice or abnormal LFTs.

Which test is performed?

The Ipsen-sponsored Cholestasis Panel (110 genes), optimized for PFIC, ALGS, and other cholestasis-associated genetic disorders.

Is genetic counseling included?

Yes.

Individuals in the US tested through the Ipsen Sponsored Cholestasis Genetic Testing Program receive no-charge post-test genetic counseling, provided by Labcorp Genetics.

Patients may schedule online or call 1-800-436-3037 to request an appointment.

How are specimens collected?

Use an Invitae (Labcorp Genetics) collection kit. Most samples can be returned at no cost using the provided shipping materials.

What is the turnaround time?

Approximately 2–3 weeks from receipt of the specimen.

How do I place an order?

Confirm eligibility, obtain consent, and order through the online portal.

Is insurance billed?

No. Testing and shipping are fully covered by the sponsor.

Test details

  • ConditionsCholestasis, Alagille Syndrome, Familial Intrahepatic Cholestasis (PFIC)
  • Test typeLarge NGS Panel
  • Test codeFV16RECO
  • Genes / markers
    110
  • Key genes / markersATP8B1, ABCB11, ABCB4, TJP2, NR1H4, MYO5B, USP53, VPS33B, VIPAS39, JAG1, NOTCH2
  • SpecimenWhole blood•Saliva•Buccal swab
  • Turnaround time10-21 Days
  • LabInvitae | Labcorp
  • Program regionUnited States

Getting started

Use the links below to review program details, place orders, print requisitions, or request collection kits.

Performing lab

Invitae | Labcorp

Available in: United States

Order test
Print requisition
Order collection kit
Learn more

Privacy & ordering: This directory doesn't handle PHI. Orders occur on participating labs' systems. Privacy & Compliance

See an issue with this program?

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