Uncovering Periodic Paralysis Panel
Genetic testing for 6 genes associated with primary periodic paralysis, including HyperPP, HypoPP, PMC, and ATS, to help clarify the cause of episodic muscle weakness.
Accessed through the Uncovering Periodic Paralysis Sponsored Testing Program•Sponsored by Xeris Pharmaceuticals•Performed by Prevention Genetics
Designed to help patients understand the purpose of testing and what to expect.
For patients
What this test and program do
Living with unexplained episodes of muscle weakness or temporary paralysis can be frightening and frustrating, especially when you do not have a clear diagnosis. The Uncovering Periodic Paralysis program provides genetic testing and genetic counseling at no cost to you, helping identify whether your symptoms may be caused by a form of periodic paralysis such as hyperkalemic or hypokalemic periodic paralysis. Xeris Pharmaceuticals sponsors the program and covers the full cost of testing, so you will never receive a bill.
Who this may help
Could this be right for you or your family?
- To qualify, all of the following must be met:
- The patient is in the US
- At least one of the following (happened more than once):
- Repeated episodes of muscle weakness or paralysis
- Repeated pain following those episodes
- At least one of the common triggers for hyperkalemic or hypokalemic periodic paralysis sets off the episodes
What to expect
How the process works
- 1
Confirm Eligibility
Your provider will review whether you meet the eligibility criteria and explain the test.
- 2
Test Is Ordered
Your provider orders the test using the online portal or paper form.
- 3
Provide Your Sample
Give a whole blood, saliva, or buccal swab sample as instructed. All samples must be labeled with two patient identifiers.
- 4
Get Your Results
The lab processes the test in about 3 weeks and sends results to your provider, who will review them with you.
Cost & coverage
Understanding potential costs
If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.
Quality & privacy
How your sample and information are handled
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Common questions about this program
What is the Uncovering Periodic Paralysis genetic testing program?
The Uncovering Periodic Paralysis program is a sponsored genetic testing program that looks at 6 genes associated with periodic paralysis. It is designed for people who experience recurring episodes of muscle weakness or temporary paralysis that may be triggered by common factors linked to hyperkalemic or hypokalemic periodic paralysis. The program also includes genetic counseling to help you understand your results.
Is the Uncovering Periodic Paralysis genetic test really free for patients?
Yes, the Uncovering Periodic Paralysis program is completely free to you. Xeris Pharmaceuticals sponsors the program and covers the entire cost of genetic testing and genetic counseling. You will not be asked to pay anything out of pocket, and there are no hidden fees, copays, or deductibles.
What kind of sample is needed for periodic paralysis genetic testing?
The Uncovering Periodic Paralysis program accepts a whole blood sample, a saliva sample, or a buccal swab (a gentle cheek swab). Your healthcare provider will order a free collection kit, and the sample can be collected in a way that works best for you. No invasive procedures are required.
How long does it take to get results from the Uncovering Periodic Paralysis test?
Results from the Uncovering Periodic Paralysis program are typically available within 2 to 3 weeks after your sample arrives at the lab. Once results are ready, your ordering healthcare provider will go over them with you. The program also includes genetic counseling to help you understand what the findings mean for you and your family.
Does the Uncovering Periodic Paralysis program include genetic counseling?
Yes, the Uncovering Periodic Paralysis program includes genetic counseling at no cost to you. A genetic counselor can help explain your test results, discuss what they may mean for your health, and answer any questions you have about periodic paralysis and next steps. This support is part of the program and covered by the sponsor.
How do I get started with free periodic paralysis genetic testing?
To get started with the Uncovering Periodic Paralysis program, talk to your doctor or healthcare provider. A clinician needs to place the order and request a sample collection kit. Once your sample is collected and sent to the lab, results are typically ready in 2 to 3 weeks. There is no cost to you at any point in the process.
Who qualifies for Uncovering Periodic Paralysis periodic paralysis genetic testing?
Patients may qualify for Uncovering Periodic Paralysis if they meet the program's eligibility criteria:
- Must be 18 years or older and live in the U.S. or a U.S. territory
- History of more than one episode of muscle weakness or paralysis, or pain following attacks
- Episodes are triggered by factors associated with HyperPP or HypoPP (e.g., cold exposure, rest after exercise, stress/fatigue, potassium-rich foods, fasting, carbohydrate-rich meals, or alcohol)
- Features consistent with:
- HyperPP: attacks with documented potassium >4.5 mEq/L
- HypoPP: attacks with hypokalemia (<2.5 mEq/L)
Questions to ask your doctor about Uncovering Periodic Paralysis Panel
- Do you think this test is appropriate for me based on my symptoms and history?
- How could the results of this test change my diagnosis or treatment plan?
- What are the potential limitations of this test that I should understand?
- Should any of my family members also be tested based on my results?
- How will we follow up after the results are available?
Notes
See an issue with this program?