Uncovering Periodic Paralysis Panel
Genetic testing for 6 genes associated with primary periodic paralysis, including HyperPP, HypoPP, PMC, and ATS, to help clarify the cause of episodic muscle weakness.
Accessed through the Uncovering Periodic Paralysis Sponsored Testing Program•Sponsored by Xeris Pharmaceuticals•Performed by Prevention Genetics
Designed to help patients understand the purpose of testing and what to expect.
For patients
What this test and program do
The Uncovering Periodic Paralysis Program offers no-cost genetic testing and genetic counseling for individuals with episodic muscle weakness or temporary paralysis often triggered by common factors associated with primary hyperkalemic or hypokalemic periodic paralysis. This testing program is sponsored by Xeris Pharmaceuticals.
Who this may help
Could this be right for you or your family?
- Must be 18 years or older and live in the U.S. or a U.S. territory
- History of more than one episode of muscle weakness or paralysis, or pain following attacks
- Episodes are triggered by factors associated with HyperPP or HypoPP (e.g., cold exposure, rest after exercise, stress/fatigue, potassium-rich foods, fasting, carbohydrate-rich meals, or alcohol)
- Features consistent with:
- HyperPP: attacks with documented potassium >4.5 mEq/L
- HypoPP: attacks with hypokalemia (<2.5 mEq/L)
What to expect
How the process works
- 1
Confirm Eligibility
Your provider will review whether you meet the eligibility criteria and explain the test.
- 2
Test Is Ordered
Your provider orders the test using the online portal or paper form.
- 3
Provide Your Sample
Give a whole blood, saliva, or buccal swab sample as instructed. All samples must be labeled with two patient identifiers.
- 4
Get Your Results
The lab processes the test in about 3 weeks and sends results to your provider, who will review them with you.
Cost & coverage
Understanding potential costs
If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.
Quality & privacy
How your sample and information are handled
Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.
Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.
FAQ
Common questions about this program
What does this genetic test look for?
This test analyzes 6 genes associated with periodic paralysis conditions, including HyperPP, HypoPP, Paramyotonia Congenita, and Andersen–Tawil Syndrome. It helps identify whether your symptoms may have a genetic cause.
Who is eligible for this program?
Adults in the U.S. or U.S. territories who have recurrent episodes of muscle weakness or paralysis, or pain after attacks, and whose episodes are triggered by common HyperPP or HypoPP triggers.
What specimens are accepted?
Whole blood, saliva, or buccal swab samples are accepted for this test.
How long does testing take?
Results are typically sent to your healthcare provider about 3 weeks after the lab receives your sample and completed paperwork.
Will I receive genetic counseling?
No-cost genetic counseling with a third-party service (provided by Genome Medical), is available to patients through this sponsored testing program. Pre-test and post-test genetic counseling appointments are available to all individuals eligible for the Uncovering Periodic Paralysis genetic testing program. Learn more.
Is this test really free?
Yes. If you meet the program’s eligibility requirements, your test is provided at no cost to you.
How will I get my results?
Your healthcare provider will receive your report and contact you to review the findings and discuss next steps.
Questions to ask your doctor about Uncovering Periodic Paralysis Panel
- Do you think this test is appropriate for me based on my symptoms and history?
- How could the results of this test change my diagnosis or treatment plan?
- What are the potential limitations of this test that I should understand?
- Should any of my family members also be tested based on my results?
- How will we follow up after the results are available?
Notes
See an issue with this program?