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Immunology / GeneticsPrimary Immunodeficiencies (PID)+Infection Susceptibility Syndromes+Immune Dysregulation & Autoinflammatory Conditions+

Invitae Primary Immunodeficiency Panel

This test analyzes genes linked to primary immunodeficiency, immune dysregulation, and autoinflammatory disorders to support diagnosis and clinical care.

Accessed through the Invitae Unlock™ Sponsored Testing Program•Sponsored by Invitae | Labcorp•Performed by Invitae | Labcorp

Designed to help patients understand the purpose of testing and what to expect.

For patients

What this test and program do

The Invitae Unlock™ Immunology program offers no-charge genetic testing for U.S. patients with suspected inherited immunodeficiencies or immune-regulation disorders. If you have recurrent infections, abnormal immune studies, or a family history of immune disease, genetic testing can help clarify diagnosis and guide care.

Who this may help

Could this be right for you or your family?

  • Resides in the United States.
  • Clinical suspicion for an inborn error of immunity (IEI), including primary immunodeficiencies or primary immune regulatory disorders.
  • See full list of qualifying clinical presentations.

What to expect

How the process works

  1. 1

    Submit an order

    Your healthcare provider will place the genetic test order online or using a paper form and include your insurance information.

  2. 2

    Collect specimen

    You’ll provide a blood, saliva, or cheek swab sample using a collection kit.

  3. 3

    Receive results

    Results are typically available 10–21 days after the lab receives your sample. Your provider will review them with you.

Cost & coverage

Understanding potential costs

If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.

Quality & privacy

How your sample and information are handled

Testing is performed by Invitae | Labcorp, a CLIA-certified laboratory (CLIA 05D2040778). Your sample is processed using validated methods and quality controls to support reliable genetic results.

Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.

FAQ

Common questions about this program

What is this test?

This genetic test looks for inherited causes of primary immunodeficiency (PID), which can lead to frequent or severe infections, poor immune responses, or other long-standing immune concerns.

Who should consider testing?

Patients in the U.S. with repeated infections, unusual illness patterns, or a clinical concern for an underlying immune disorder may be eligible. Your provider will decide if this test fits your situation.

What will the test cost?

Labcorp first reviews your insurance coverage. If testing is covered, your insurance may be billed after results are released. If you have no coverage, your plan excludes genetic testing, or you don’t meet insurance eligibility rules, you may qualify for a sponsored, no-charge option.

Will my information be shared?

De-identified patient information and your clinician’s contact details may be shared with researchers or commercial partners, regardless of whether insurance or a sponsored option is used.

How do I provide a sample?

Your provider will place the order. A blood, saliva, or buccal sample may be collected depending on what they recommend.

When will I get results?

Most results are returned within the lab’s standard turnaround time once your sample arrives.

Who explains my results?

Your results will be sent to your ordering provider, who will review them with you and discuss next steps.

Test details

  • Conditions
    Primary Immunodeficiencies (PID), Infection Susceptibility Syndromes, Immune Dysregulation & Autoinflammatory Conditions
  • Test typeLarge NGS Panel
  • Test code08100
  • Genes / markers
    429
  • Key genes / markersIL2RG, JAK3, RAG1, RAG2, ADA, BTK, CYBB, CYBA, NCF1, NCF2, NCF4, STAT1, STAT3, MYD88, IRAK4, CTLA4, LRBA, FOXP3, TNFRSF13B, PRF1
  • SpecimenWhole blood•Saliva•Buccal swab•gDNA
  • Turnaround time10-21 Days
  • LabInvitae | Labcorp
  • Program regionUnited States

Next steps

Share this information with your immunologist or genetic specialist. They can help determine whether this test and program are appropriate for you.

Or ask your doctor to search for this test by name at Invitae | Labcorp.

Other Tests in This Program

Invitae Inborn Errors of Immunity and Cytopenias Panel

Invitae Unlock™•Invitae | Labcorp

Invitae Inherited Retinal Disorders Panel

Invitae Unlock™•Invitae | Labcorp

Invitae Epilepsy Panel

Invitae Unlock™•Invitae | Labcorp

Invitae Arrhythmia and Cardiomyopathy Comprehensive Panel

Invitae Unlock™•Invitae | Labcorp

Questions to ask your doctor about Invitae Primary Immunodeficiency Panel

  1. Do you think this test is appropriate for me based on my symptoms and history?
  2. How could the results of this test change my diagnosis or treatment plan?
  3. What are the potential limitations of this test that I should understand?
  4. Should any of my family members also be tested based on my results?
  5. How will we follow up after the results are available?

Notes

See an issue with this program?

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