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Endocrinology / MetabolicFamilial Chylomicronemia Syndrome (FCS)

Familial Chylomicronemia Panel

7-gene genetic test at no cost for individuals with suspected FCS and severe hypertriglyceridemia, helping confirm diagnosis and guide care.

Accessed through the Familial Chylomicronemia Syndrome (FCS) Sponsored Testing Program•Sponsored by Ionis Pharmaceuticals•Performed by Prevention Genetics

Designed to help patients understand the purpose of testing and what to expect.

For patients

What this test and program do

This sponsored testing program provides no-cost genetic testing for individuals in the U.S. or Canada with severe refractory hypertriglyceridemia (sHTG) suggestive of familial chylomicronemia syndrome (FCS). The test helps identify genetic causes of extremely elevated triglyceride levels and supports more informed care decisions. Both pre- and post-test genetic counseling are available at no charge through Genome Medical.

Who this may help

Could this be right for you or your family?

  • You must live in the United States or Canada.
  • You may qualify if you have two or more fasting triglyceride results above 880 mg/dL (10 mmol/L).
  • Your high triglycerides must not be caused by another medical condition or secondary factor.
  • You must be able to provide informed consent to participate.

What to expect

How the process works

  1. 1

    Check Eligibility & Learn About Testing

    Your provider will confirm you meet the program’s eligibility criteria and discuss the test. Optional pre-test genetic counseling is available through Genome Medical.

  2. 2

    Your Provider Orders the Test

    Your provider will order the test using the U.S. or Canadian requisition form.

  3. 3

    Provide a Sample

    You’ll provide a blood, saliva, or buccal sample. All samples must be labeled with two identifiers. Your provider will handle shipping and kit instructions.

  4. 4

    Receive Results & Counseling

    Results are sent to your provider in about 18 days. Your provider will review them with you, and optional post-test genetic counseling is available through Genome Medical.

Cost & coverage

Understanding potential costs

If you qualify for this program, the sponsor works with the laboratory to help make testing more affordable. Many patients pay little or no out-of-pocket cost. Your exact cost will depend on your insurance coverage and the specific criteria of the program, and the lab can explain what to expect before your sample is processed.

Quality & privacy

How your sample and information are handled

Testing is performed by Prevention Genetics, a CLIA-certified laboratory (CLIA 52D2065132) and College of American Pathologists (CAP) certified laboratory (CAP 7185561). Your sample is processed using validated methods and quality controls to support reliable genetic results.

Your health information is handled under privacy and security practices that are intended to align with applicable regulations. For program- and lab-specific details, review the privacy information provided by the laboratory and sponsor.

FAQ

Common questions about this program

What is this testing program?

This program offers no-cost genetic testing for people with very high triglyceride levels that may be caused by familial chylomicronemia syndrome (FCS) or related genetic conditions. Testing helps clarify the underlying cause and guide care.

Who is eligible?

You must live in the United States or Canada and have at least two fasting triglyceride results above 880 mg/dL (10 mmol/L) that cannot be explained by another medical condition. Your provider will confirm eligibility.

What does the test look for?

The test examines genes linked to FCS and severe refractory hypertriglyceridemia. Identifying a genetic cause can help your care team determine the best management plan.

Do I have to pay for the test?

No. The test and optional genetic counseling are offered at no cost through the sponsored testing program.

How long do results take?

Results are sent to your healthcare provider about 18 days after the lab receives your sample and paperwork.

Is genetic counseling available?

Yes. Free pre-test and post-test genetic counseling is available through Genome Medical to help you understand your results.

Test details

  • ConditionFamilial Chylomicronemia Syndrome (FCS)
  • Test typeNGS
  • Test code13025
  • Genes / markers
    7
  • Key genes / markersAPOA5, APOC2, CREB3L3, GPD1, GPIHBP1, LMF1, LPL
  • SpecimenWhole blood•Saliva•Buccal swab
  • Turnaround time2-3 Weeks
  • LabPrevention Genetics
  • Program regionUnited States, Canada

Next steps

Share this information with your healthcare provider or genetic specialist. They can help determine whether this test and program are appropriate for you.

Or ask your doctor to search for this test by name at Prevention Genetics.

Questions to ask your doctor about Familial Chylomicronemia Panel

  1. Do you think this test is appropriate for me based on my symptoms and history?
  2. How could the results of this test change my diagnosis or treatment plan?
  3. What are the potential limitations of this test that I should understand?
  4. Should any of my family members also be tested based on my results?
  5. How will we follow up after the results are available?

Notes

See an issue with this program?

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