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KEYTRUDA + LENVIMA

Therapy

A combination of pembrolizumab (Merck) and lenvatinib (Eisai) used in select biomarker-defined endometrial and renal cancers.

Approvals
2
Indications
1
Biomarkers
2
Mapped tests
2

Where this therapy is approved with a companion diagnostic

Each row represents a defined combination of indication, biomarker criteria, and KEYTRUDA + LENVIMA. Select a testing pathway to see the eligible companion diagnostic tests.

Indication-specific approvals

Approvals where KEYTRUDA + LENVIMA is tied to a specific indication and biomarker definition.

IndicationBiomarker criteriaNotes
Endometrial Carcinoma (EC)
Solid Tumor · Endometrium
Not MSI-High
  • Not Microsatellite Instability-High (Not MSI-H)
View testing pathway →
Endometrial Carcinoma (EC)
Solid Tumor · Endometrium
proficient mismatch repair (pMMR) proteins
  • MLH1, PMS2, MSH2 and MSH6
View testing pathway →
Tumor-agnostic approvals

Approvals defined at the solid tumor level where biomarker criteria determine eligibility for KEYTRUDA + LENVIMA.

No tumor-agnostic companion diagnostic approvals are currently mapped for this therapy.

Tests used in these approvals

These assays are identified in FDA labeling or sponsor materials as companion diagnostics or acceptable tests when considering KEYTRUDA + LENVIMA for eligible patients.

Test
MI Cancer Seek (MCS)
Caris Life Sciences
Method
NGS
Specimen
Tissue (FFPE)
Test
Ventana MMR RxDx Panel
Ventana Medical Systems, Inc. (Roche Diagnostics)
Method
IHC
Specimen
Tissue (FFPE)
This view is scoped to KEYTRUDA + LENVIMA. You can also see how it compares with other therapies and indications on the main Know Your Companions™ map.