ESR1
ESR1 encodes the estrogen receptor and is central to hormone-driven breast cancer biology. Acquired mutations can confer resistance to endocrine therapies and guide treatment decisions.
Where this biomarker is used
Each approval combines this biomarker with a specific indication and therapy. Select a therapy in the tables below to open its FDA-defined testing pathway.
Approvals where ESR1 is defined directly in the indication labeling.
| Indication | Biomarker criteria | Therapies |
|---|---|---|
Breast Cancer Solid Tumor · Breast |
|
Approvals defined at the solid tumor level where ESR1 is part of the eligibility criteria.
No tumor-agnostic approvals are currently mapped for this biomarker.
Tests that measure this biomarker
These assays report ESR1 as part of their validated menu. In many cases they are identified in FDA labeling as acceptable companion diagnostics for specific approvals.
Reports ESR1 as part of its biomarker panel.